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9 Best Enzyme Drain Cleaners of 2021 – Reviews & Top Picks

Best Enzyme Drain CleanersEnzyme drain cleaners are highly effective, but products differ substantially. You want the best product you can get your hands on, but you don’t know how to get it. You know that the right product will fix up your drains effortlessly, while the wrong one could even damage them. But how to tell one from the other?

Guides like this make it much easier. We’ve taken a look at a wide range of products and distilled our findings to the top 10 units on the market. Bottom line? Read on for our enzyme drain cleaner reviews!

Quick Comparison of Our Favorites in 2021

Image Product Details
Best Overall
Flo-Kem Flo-Zyme Flo-Kem Flo-Zyme
  • Industrial strength
  • Sizable container
  • Deodorizes
  • Premium Choice
    Second place
    Bio-clean Drain Cleaners Bio-clean Drain Cleaners
  • Up to one hundred uses
  • Potent
  • Very versatile
  • Third place
    Green Gobbler Enzyme Green Gobbler Enzyme
  • Moderate price
  • Odor eating
  • Fairly quick
  • Bioda Drain Cleaner Bioda Drain Cleaner
  • Versatile
  • Affordable
  • Good at odor eating
  • Helix Laboratories BioFresh Enzyme Helix Laboratories BioFresh Enzyme
  • Very strong
  • Versatile
  • Odor elimination
  • The 9 Best Enzyme Drain Cleaners

    1. Flo-Kem Flo-Zyme Drain Opener — Best Overall

    Flo-Kem 5195 Flo-Zyme Drain Opener

    The Flo-Kem comes in a gallon-sized container and works to break up grease stains while also deodorizing the pipes. It is specifically designed to treat runoff drains, especially in an industrial setting. The chemical compound is made to eliminate rotten egg odors that commonly accumulate in waste drains.

    Buyers will also want to keep in mind that it features a shelf life of one year—not the longest you will encounter, but still sufficient enough to ensure you have ample opportunity to use the entire container.

    We’ve heard reports from some users that the solution does not work well with older pipes. However, it is somewhat difficult to determine whether this is a fault of the product or a matter of improper use. Nevertheless, you may want to consider the age of your plumbing before you purchase this product.

    • Industrial strength
    • Sizable container
    • Deodorizes
    • May not work well on older drains

    2. Bio-clean Drain Cleaners — Premium Choice

    Bio-clean SYNCHKG016874 Drain Cleaners

    The Bio-Clean is a two-pound container that benefits from an industrial quality strength. The enzymes at work in the formula are able to quickly digest dead organic waste, and the container gives you over 100 treatments.

    It’s also very versatile. The solution can be used for sinks, showers, septic tanks, and more. All this utility comes at quite the price, though. This is a highly expensive cleaner that won’t suit the needs of the buyer on a budget. If you don’t mind shelling out for a really potent cleaner, this will be a great option to consider though.

    • Up to one hundred uses
    • Potent
    • Very versatile
    • Very pricey

    3. Green Gobbler Enzyme Drain Cleaner

    Green Gobbler 8541814331 Enzyme Drain Cleaner

    The Green Gobler is an effective and moderately priced unit that will be good for people that want something affordable and effective. The compound has been infused with an odor-eating property that will make your drains smell better every time you use it.

    The product is also made to be fairly swift. Thanks to the effectiveness of the solution, you can break down fats, as well as hair and other organic matter with ease.

    One of the biggest issues with this product is that it needs to be used frequently for maximum effectiveness. For major clogs, you may wind up using it twice weekly, which cuts against the value somewhat. It’s certainly not completely hopeless but it does have its drawbacks.

    • Moderate price
    • Odor eating
    • Fairly quick
    • Needs frequent use for maximum effectiveness

    4. Bioda Drain Cleaner

    Bioda BEB-00013 Drain Cleaner

    The Bioda is a multi-purpose cleaner that can be used with pipes and septic tanks. While it is not scented, it does neutralize bad odors, and it can be used to effectively prevent clogs from ever occurring. For a moderate price, you get a gallon-sized container that should last a decent amount of time.

    The average treatment requires just half a cup of solution, which means you should get 30 or more uses out of a single container.

    There is, however, a persistent user complaint. Many who regularly use this product claim that it is much better at odor elimination than it is at preventing clogs. While it will work with smaller issues, it won’t do great against major clogs.

    • Versatile
    • Affordable
    • Good at odor eating
    • Not great at major clogs

    5. Helix Laboratories BioFresh Enzyme Drain Cleaner

    Helix Laboratories BioFresh Enzyme Drain Cleaner

    The Helix Laboratories product advertises itself as a double strength container. While this description may or may not be fair (after all, what are they comparing it to?), it is safe to say that it is stronger than many of the other products on the market.

    It is good for drains, appliances, etc., and claims to also be good at eliminating fruit flies, which are often attracted to the organic matter build-up in your drainage systems. It is also designed to eliminate odors, which will be great for people who are dealing with challenging smells.

    Unfortunately, it is on the expensive side, especially relative to the size of the container. For the same money that you spend on this gallon container, you could buy several others from a comparable brand.

    • Very strong
    • Versatile
    • Odor elimination
    • Pricey
    • Value concerns

    6. Breaks Down Grease Drain Cleaner

    Breaks Down Grease Drain Cleaner

    The aptly named “Breaks Down Grease Drain Cleaner” is a moderately priced, gallon-sized unit that will be good for buyers on a budget. The chemicals are biodegradable, which means they will slowly degrade into minerals and water to reduce the environmental impact.

    It is also relatively fast-acting. The odor-eating component kicks in within hours, which is great for people who are really fed up with a grease odor in their pipes.

    Perhaps best of all, you even get a money-back guarantee. If, after 30 days, you’ve decided that this product wasn’t effective, you can get a complete refund.

    Unfortunately, many users have reported problems with household use. The product is better at eliminating grease than it is other types of organic waste. In other words, it may not do so well with toilets, showers, and bathroom sinks.

    • Moderate price
    • Fast-acting de-scenting component
    • Money-back guarantee
    • Not great with certain types of waste

    7. Black Diamond Enzyme Drain Opener

    Black Diamond GTT-G Enzyme Drain Opener

    The Black Diamond unit is made specifically for industrial purposes. This means that restaurants with grease traps or other highly-stressed drains and pipes will benefit the most from this product. The solution is biodegradable and benefits from a two-year shelf life that is roughly twice the length of many comparable products.

    The container is sized at one gallon, and the recommended dosage is around 4-6 ounces (depending on the severity of the clog). This gives you approximately 32 treatments from each container.

    Unfortunately, like many of the more industrially oriented units, it isn’t extremely great for other, more human forms of organic matter. This means it’s not super great for septic tanks, bathroom sinks, showers, or toilets.

    • Plenty of uses
    • Good for industrial purposes
    • Not great for human organic matter

    8. Earthworm Drain Cleaner

    Earthworm Drain Cleaner

    The Earthworm Drain Cleaner is a half-gallon-sized container. The unit is designed specifically for slow draining sinks and drains, and is naturally infused with a citrus smell that many users may find pleasing. The process is completely natural and similar to the approach that the human body uses to break down waste.

    Unfortunately, there are a couple of reasons why this product finds itself at the bottom of our list. For one thing, it is fairly limited in its effectiveness. A substantial amount of solution is required for eliminating clogs. This issue also cuts sharply against the value of the unit. You will go through quite a bit of the chemical getting rid of clogs, which can make it expensive.

    • Citrus smell
    • Natural
    • Not great for eliminating clogs
    • Value concerns

    9. Harris EDC-18 Enzyme Drain Cleaner

    Harris EDC-18 Enzyme Drain Cleaner

    The Harris EDC is an affordable unit that is designed to provide approximately 40 treatments. In terms of sheer value, it’s an extremely enticing option for the buyer on the budget. The unit also advertises itself as being biodegradable and highly effective.

    The problem is that it doesn’t deliver so well on the promises it makes. For one thing, it takes quite a bit of solution to clear out most clogs. That means you probably won’t get the 40 treatments promised by the advertisement.

    A bigger problem is that many users are reporting that it has caused unsightly brown staining in their sinks, tubs, toilets, etc. The bottom line is that many users are likely to be better served by spending a little bit more money to get a better product.

    • Biodegradable
    • Not very effective
    • Value concerns
    • Brown staining

    Buying Considerations

    And now, let’s take a look at some buying considerations that should help make your choice a little bit easier. Read on!

    First, Why Enzymes?

    Enzymes are biological molecules that facilitate all of the chemical reactions that occur within cells, most typically in the human body. We have tens of thousands of enzymes working their magic at any given time to process the food we eat.

    The great thing about enzyme cleaners is that they are specifically optimized for breaking down organic matter. This means that they will work wonders on grease, hair, and other nastiness that finds itself lining our pipes.

    Similarly, they won’t harm inorganic matter. This means that even the most potent degreaser won’t do any harm to your plastic pipes.

    Of course, there are cons that come with selecting enzyme degreasers as well. They aren’t quite as potent as some of the other options on the market. Unfortunately, this means it might take them days to do what other cleaners can do in minutes.

    Still, if you want something safe and effective (especially at eliminating grease) this is going to be the product for you.


    While the intention of any enzyme cleaner will always be to take out organic matter, there is some variation from product to product. For example, some cleaners are great for industrial applications.

    Restaurants might appreciate these products for their ability to clean grease traps or sinks that are clogged up with food residue.

    There are also options that will be better suited for home use. These products specifically target showers, bathroom sinks, and toilets. While many products are at least relatively effective at both applications, it will probably be better for you to choose something that is targeted for your purposes.

    Size of the Container

    The size of the container will ultimately determine the value. Larger units tend to cost more, but they also wind up giving you more bang for your buck. In other words, a single one-gallon unit will probably cost less than a single five-gallon unit. However, buying five one-gallon containers will usually cost more than buying a single five-gallon container.


    Of course, buying in bulk isn’t right for everyone. For one thing, budget buyers may not be able to swing the higher price tag, regardless of long term savings. Larger containers are also heavier, more difficult to store, and more likely to expire on the shelf depending on how often you use the chemicals.

    As with anything, different products will be right for different people.

    Drainage Cleaner
    Featured Image Credit: Breaks Down Grease Drain Cleaner, Amazon

    Treatment Volume

    How much of the solution needs to be used during each treatment? This number may vary quite substantially from product to product. Higher quality solutions tend to be very potent, and therefore do not require much volume at all.

    Other units are a little bit more watered down and require a higher quantity of chemicals. For example, you may find a gallon container that is good for 32 treatments or a quart-sized container that is good for 100.

    Unfortunately, manufacturers don’t always put dosage instructions in their product descriptions, which makes it harder to factor for this consideration. However, when this information is available, it will be to your benefit to take it into consideration.

    Shelf Life

    With chemicals, shelf life is essentially synonymous with expiration date. Even industrial strength cleaners will go bad eventually. Standard shelf life will hover somewhere around a year in length. However, there is certainly variation in both directions so pay close attention to this factor.

    Granted, the importance of the expiration date will also vary substantially depending on the type of user. For example, if you are degreasing the drains of a fast-food restaurant, you really don’t need to worry too much about shelf life. Chances are pretty good that your chemicals won’t grow old on the shelf.

    However, if you are just trying to take care of your house pipes, you probably won’t have nearly the same need. In that case, the shelf life will be a very prominent consideration indeed.


    As illustrated above, the value of a product is determined largely by the price per gallon. Unfortunately, enzyme cleaners are pretty pricey, with an average unit costing somewhere in the neighborhood of $20 per gallon.

    You can certainly find units that cost more or less than this figure, but if you’re trying to go into the process with a well-defined budget, $20 per gallon is a good rough estimate.

    Odor Eating

    This next consideration is a little bit tricky because pretty much every manufacturer claims that their product eliminates odor. However, some of the claims are far more accurate than others. While it is technically true that everyone is being honest, some of the claims are being made on the basis that the solution is eliminating grease, and therefore, the smell it contains.

    Enzyme Cleaners
    Featured Image Credit: Peakpx

    That’s great, but it also isn’t the rapid odor solution some people will be looking for. If you are really trying to get rid of a nasty smell, you’ll want to invest in something that is scented.

    Scented products can eliminate a bad smell in minutes, while other, unscented units may take days to start working.

    Pay close attention to the wording of the product description to be sure you are getting exactly what you want.


    You may have noticed that some of the products are advertised as being biodegradable. This means that over time, the chemicals will reduce down to their basic parts, subsequently minimizing the impact it has on the environment.

    Even if you don’t care about ecology, you will probably want to invest in something that is biodegradable. Why? Biodegradable products won’t build-up on the side of your pipes the way that other cleaners will.

    It’s a true win-win.


    Unfortunately, there are too many variables at work to know for absolute certain that a given product will be effective in your situation. For example, some cleaners don’t work so well with older pipe systems. Others are great at handling grease, but not so good at handling your hair clog problem.

    In any case, it helps to have a guarantee working in your favor. Consequently, some manufacturers provide exactly that, giving you your money back if you aren’t pleased with the results after 30 days.

    You don’t necessarily need this feature but it does provide you with a nice safety net.


    Some units advertise themselves on the basis of their ability to provide preventative care. These solutions are great for houses that experience regular clogs. However, they aren’t so great at dealing with built-up grease.

    These units tend to be a little bit milder, and they need to be used on a regular (usually monthly) basis. While they will be good for nipping issues in the bud, they won’t be so good for other applications, so plan accordingly.


    Did one of our enzyme drain cleaner reviews speak to you? Hopefully, you’ve already found and purchased your ideal product. If not though, it may be to your benefit to look at some of the standout choices featured here today.

    Our top choice, the Flo-Kem 5195 Flo-Zyme Drain Opener is going to be great for people that are comfortable spending more on really good products. However, the buyer on the budget will probably favor something more like our runner up, the Zep DC16 Drain Care Build-Up Remover.

    Featured Image Credit: Pikrepo

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